Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Uveitis, Intermediate
CUI: C0042166
Disease: Uveitis, Intermediate
0.010 GeneticVariation BEFREE The frequency of carriers of the minor allele for rs1800795 was significantly higher in patients with intermediate uveitis compared to controls (p = 0.04; OR: 1.46; CI: 1.02-2.11). 26640809 2015
Uveitis
CUI: C0042164
Disease: Uveitis
0.010 GeneticVariation BEFREE Frequencies of the minor allele for rs1800795 did not differ significantly in patients with HLAB27 associated uveitis when compared to controls (p > 0.05). 26640809 2015
Urinary tract infection
CUI: C0042029
Disease: Urinary tract infection
0.010 GeneticVariation BEFREE Associations were found between the CC genotype of IL6 SNP rs1800795 and occurrence of bacteremia and between TLR5 SNP rs5744168 and protection from UTI. 25807366 2015
Tuberculosis, Pulmonary
CUI: C0041327
Disease: Tuberculosis, Pulmonary
0.010 GeneticVariation BEFREE The aim of this study was to evaluate the association between previously reported SNPs IL2-330 T>G (rs2069762); IL4-590 C>T (rs2243250); IL6-174 G>C (rs1800795); IL10-592 A>C (rs1800872); IL10-1082 G>A (rs1800896); IL17A -692 C>T (rs8193036); IL17A -197 G>A (rs2275913); TNF -238 G>A (rs361525); TNF -308 G>A (rs1800629) and IFNG +874 T>A (rs2430561) and pulmonary TB (PTB) susceptibility. 26840977 2016
Tuberculosis
CUI: C0041296
Disease: Tuberculosis
0.040 GeneticVariation BEFREE GG genotypes of rs1800795 in IL-6 was also associated with occurrence of tuberculosis in our patients with TA. 28438554 2018
Tuberculosis
CUI: C0041296
Disease: Tuberculosis
0.040 GeneticVariation BEFREE Collectively, this meta-analysis proved that IL-6 rs1800795, IL-18 rs1946518 and IL-18 rs187238 polymorphisms may confer susceptibility to TB, especially for Asians. 31676365 2020
Tuberculosis
CUI: C0041296
Disease: Tuberculosis
0.040 GeneticVariation BEFREE Collectively, this meta-analysis proved that IL-2 rs2069762, IL-4 rs2243250, IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871 and IL-10 rs1800896 polymorphisms may confer susceptibility to TB, especially for Asians. 31669382 2020
Tuberculosis
CUI: C0041296
Disease: Tuberculosis
0.040 GeneticVariation BEFREE Collectively, this meta-analysis proved that IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872 and IL-10 rs1800896 may confer susceptibility to TB. 31560754 2019
Tinnitus
CUI: C0040264
Disease: Tinnitus
0.010 GeneticVariation BEFREE We found significant association between the genotype and allele frequencies of the IL6 -174 gene (rs1800795) and tinnitus among the elderly with history of exposure to occupational noise (P = 0.03). 26572700 2016
Thrombosis of cerebral veins
CUI: C0151945
Disease: Thrombosis of cerebral veins
0.010 GeneticVariation BEFREE We conducted a case-control study to investigate the influence of IL6 -174G/C (rs1800795) and -572C/G (rs1800796) genetic variants on the development of cerebral thrombosis in a Chinese population. 26662441 2015
Takayasu Arteritis
CUI: C0039263
Disease: Takayasu Arteritis
0.010 GeneticVariation BEFREE GG genotypes of rs1800795 in IL-6 was also associated with occurrence of tuberculosis in our patients with TA. 28438554 2018
Systemic Scleroderma
CUI: C0036421
Disease: Systemic Scleroderma
0.010 GeneticVariation BEFREE In the IL6 allelic combination analyses, the GGC allelic combination rs2069827-rs1800795-rs2069840 showed an association with overall SSc (Bonferroni p = 0.016, OR 1.13, 95% CI 1.04-1.23). 23027890 2012
Stomach Diseases
CUI: C0038354
Disease: Stomach Diseases
0.010 GeneticVariation BEFREE In view of the involvement of the IL-6 law and the presence of H. pylori in the development of gastric diseases, the present study aimed to characterize the promoter-region polymorphism -597 (G/A) (rs1800797), -572 (C/G) (rs1800796), and -174 (G/C) (rs1800795) by PCR-RFLP in 375 gastric biopsy specimens from patients with peptic symptoms. 30525242 2019
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.020 GeneticVariation BEFREE Epidemiological studies have evaluated the associations between interleukin-6 (IL-6) gene -174 C/G (rs1800795) and -572 C/G (rs1800796) polymorphisms and gastric cancer (GC) risk, but results and conclusions remain controversial. 22711691 2012
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.020 GeneticVariation BEFREE The prognostic role of the functional IL-6 (promoter) rs1800795 and the IL-6R (receptor) rs8192284 single nucleotide polymorphisms (SNP) was studied in patients with advanced gastric cancer treated with palliative chemotherapy. 24886605 2014
Steatohepatitis
CUI: C2711227
Disease: Steatohepatitis
0.010 GeneticVariation BEFREE In contrast, the IL6 rs1800795 C allele may confer a higher risk for steatosis, but less parenchymal damage. 27730688 2016
Sleep Apnea, Obstructive
CUI: C0520679
Disease: Sleep Apnea, Obstructive
0.010 GeneticVariation BEFREE The study was conducted to investigate the association of CRP rs1130864 (1444C/T), IL-6 rs1800795 (-174G/C) and LEPR rs1137101 (Q223R) genes with OSA and NAFLD in Asian Indians residing in North India. 30001365 2018
Severe Sepsis
CUI: C1719672
Disease: Severe Sepsis
0.010 GeneticVariation BEFREE The genotype results demonstrated that carriers of the TNF-α rs1800629 A allele had a 4.28-fold higher risk for septic shock (adjusted odds ratio [OR], 4.28; 95% confidence interval [CI], 2.24-8.18; P < .01) compared with severe sepsis, and carriers of the IL-6 rs1800795 C allele had a 2.42-fold higher risk for septic shock (OR, 2.42; 95% CI, 1.08-5.45; P < .01) compared with severe sepsis. 26025100 2015
Septicemia
CUI: C0036690
Disease: Septicemia
0.010 GeneticVariation BEFREE In the present study, we aim to investigate the association of promoter-region polymorphisms IL-6 (-174G/C) rs1800795 and TNF-α (-308G/A) rs1800629 with pneumonia-induced sepsis. 26025100 2015
Sepsis
CUI: C0243026
Disease: Sepsis
0.010 GeneticVariation BEFREE In the present study, we aim to investigate the association of promoter-region polymorphisms IL-6 (-174G/C) rs1800795 and TNF-α (-308G/A) rs1800629 with pneumonia-induced sepsis. 26025100 2015
Seizures
CUI: C0036572
Disease: Seizures
0.010 GeneticVariation BEFREE The genotypic association of rs1800795 with seizure frequency and drug-refractory epilepsy raises the issue that a specific set of polymorphic genes can influence seizures and therapeutic response in epilepsy. 22578659 2012
Secondary Neoplasm
CUI: C2939419
Disease: Secondary Neoplasm
0.010 GeneticVariation BEFREE The initial study suggested that GG relative to CG at rs1800795 (OR 1.52; 95% CI 1.14-2.02; p = 0.004) was significantly associated with the development of metastases. 28732081 2017
Secondary malignant neoplasm of colon and/or rectum
0.010 GeneticVariation BEFREE Associations between potentially functional IL6 (rs2069837 and rs1800795) and STAT3 (rs744166 and rs4796793) SNPs and clinical outcomes [progression-free survival (PFS), overall survival, and tumor response rate] were evaluated in mCRC patients receiving first-line FOLFIRI plus bevacizumab in two randomized phase III trials: TRIBE (n = 223, training cohort) and FIRE-3 (n = 288, validation cohort). 26839145 2016
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.030 GeneticVariation BEFREE Our first time observations suggest a significant relationship between IL-6 rs1800795</span> and reduced hippocampal volume in antipsychotic-naïve schizophrenia. 24787542 2014
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.030 GeneticVariation BEFREE In conclusion, we report an association of IL6 rs1800795 and higher IL-6 with schizophrenia. 22571276 2012