|
Uveitis, Intermediate
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequency of carriers of the minor allele for rs1800795 was significantly higher in patients with intermediate uveitis compared to controls (p = 0.04; OR: 1.46; CI: 1.02-2.11).
|
26640809 |
2015 |
|
Uveitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Frequencies of the minor allele for rs1800795 did not differ significantly in patients with HLAB27 associated uveitis when compared to controls (p > 0.05).
|
26640809 |
2015 |
|
Urinary tract infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
Associations were found between the CC genotype of IL6 SNP rs1800795 and occurrence of bacteremia and between TLR5 SNP rs5744168 and protection from UTI.
|
25807366 |
2015 |
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the association between previously reported SNPs IL2-330 T>G (rs2069762); IL4-590 C>T (rs2243250); IL6-174 G>C (rs1800795); IL10-592 A>C (rs1800872); IL10-1082 G>A (rs1800896); IL17A -692 C>T (rs8193036); IL17A -197 G>A (rs2275913); TNF -238 G>A (rs361525); TNF -308 G>A (rs1800629) and IFNG +874 T>A (rs2430561) and pulmonary TB (PTB) susceptibility.
|
26840977 |
2016 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
GG genotypes of rs1800795 in IL-6 was also associated with occurrence of tuberculosis in our patients with TA.
|
28438554 |
2018 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that IL-6 rs1800795, IL-18 rs1946518 and IL-18 rs187238 polymorphisms may confer susceptibility to TB, especially for Asians.
|
31676365 |
2020 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that IL-2 rs2069762, IL-4 rs2243250, IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871 and IL-10 rs1800896 polymorphisms may confer susceptibility to TB, especially for Asians.
|
31669382 |
2020 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872 and IL-10 rs1800896 may confer susceptibility to TB.
|
31560754 |
2019 |
|
Tinnitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found significant association between the genotype and allele frequencies of the IL6 -174 gene (rs1800795) and tinnitus among the elderly with history of exposure to occupational noise (P = 0.03).
|
26572700 |
2016 |
|
Thrombosis of cerebral veins
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conducted a case-control study to investigate the influence of IL6 -174G/C (rs1800795) and -572C/G (rs1800796) genetic variants on the development of cerebral thrombosis in a Chinese population.
|
26662441 |
2015 |
|
Takayasu Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
GG genotypes of rs1800795 in IL-6 was also associated with occurrence of tuberculosis in our patients with TA.
|
28438554 |
2018 |
|
Systemic Scleroderma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the IL6 allelic combination analyses, the GGC allelic combination rs2069827-rs1800795-rs2069840 showed an association with overall SSc (Bonferroni p = 0.016, OR 1.13, 95% CI 1.04-1.23).
|
23027890 |
2012 |
|
Stomach Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
In view of the involvement of the IL-6 law and the presence of H. pylori in the development of gastric diseases, the present study aimed to characterize the promoter-region polymorphism -597 (G/A) (rs1800797), -572 (C/G) (rs1800796), and -174 (G/C) (rs1800795) by PCR-RFLP in 375 gastric biopsy specimens from patients with peptic symptoms.
|
30525242 |
2019 |
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Epidemiological studies have evaluated the associations between interleukin-6 (IL-6) gene -174 C/G (rs1800795) and -572 C/G (rs1800796) polymorphisms and gastric cancer (GC) risk, but results and conclusions remain controversial.
|
22711691 |
2012 |
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The prognostic role of the functional IL-6 (promoter) rs1800795 and the IL-6R (receptor) rs8192284 single nucleotide polymorphisms (SNP) was studied in patients with advanced gastric cancer treated with palliative chemotherapy.
|
24886605 |
2014 |
|
Steatohepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, the IL6 rs1800795 C allele may confer a higher risk for steatosis, but less parenchymal damage.
|
27730688 |
2016 |
|
Sleep Apnea, Obstructive
|
|
0.010 |
GeneticVariation
|
BEFREE |
The study was conducted to investigate the association of CRP rs1130864 (1444C/T), IL-6 rs1800795 (-174G/C) and LEPR rs1137101 (Q223R) genes with OSA and NAFLD in Asian Indians residing in North India.
|
30001365 |
2018 |
|
Severe Sepsis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genotype results demonstrated that carriers of the TNF-α rs1800629 A allele had a 4.28-fold higher risk for septic shock (adjusted odds ratio [OR], 4.28; 95% confidence interval [CI], 2.24-8.18; P < .01) compared with severe sepsis, and carriers of the IL-6 rs1800795 C allele had a 2.42-fold higher risk for septic shock (OR, 2.42; 95% CI, 1.08-5.45; P < .01) compared with severe sepsis.
|
26025100 |
2015 |
|
Septicemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we aim to investigate the association of promoter-region polymorphisms IL-6 (-174G/C) rs1800795 and TNF-α (-308G/A) rs1800629 with pneumonia-induced sepsis.
|
26025100 |
2015 |
|
Sepsis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we aim to investigate the association of promoter-region polymorphisms IL-6 (-174G/C) rs1800795 and TNF-α (-308G/A) rs1800629 with pneumonia-induced sepsis.
|
26025100 |
2015 |
|
Seizures
|
|
0.010 |
GeneticVariation
|
BEFREE |
The genotypic association of rs1800795 with seizure frequency and drug-refractory epilepsy raises the issue that a specific set of polymorphic genes can influence seizures and therapeutic response in epilepsy.
|
22578659 |
2012 |
|
Secondary Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
The initial study suggested that GG relative to CG at rs1800795 (OR 1.52; 95% CI 1.14-2.02; p = 0.004) was significantly associated with the development of metastases.
|
28732081 |
2017 |
|
Secondary malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
Associations between potentially functional IL6 (rs2069837 and rs1800795) and STAT3 (rs744166 and rs4796793) SNPs and clinical outcomes [progression-free survival (PFS), overall survival, and tumor response rate] were evaluated in mCRC patients receiving first-line FOLFIRI plus bevacizumab in two randomized phase III trials: TRIBE (n = 223, training cohort) and FIRE-3 (n = 288, validation cohort).
|
26839145 |
2016 |
|
Schizophrenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our first time observations suggest a significant relationship between IL-6 rs1800795</span> and reduced hippocampal volume in antipsychotic-naïve schizophrenia.
|
24787542 |
2014 |
|
Schizophrenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
In conclusion, we report an association of IL6 rs1800795 and higher IL-6 with schizophrenia.
|
22571276 |
2012 |